An update on oral dispersible tablets

Abstract

Oral solid dosage forms are by far the most preferable and widely used dosage form, although it still has some limitations, such as 1st pass metabolism, GI adverse effects, and prolonged onset of action as compared to injectable products. Oral dispersible tablet (ODT) system presents a solution to these problems, by providing rapid onset of action, reduce 1st pass metabolism, and prevent GI adverse effects. This is achieved by using superdisintegrants which decrease the disintegration time and provide rapid action and better bioavailability. This study is aimed at reviewing the various kinds of superdisintegrants and their action.