Formulation and characterization of curcumin nanoparticles prepared from eudragit L-100 and poly vinyl alcohol as polymer

Abstract

The purpose of the study is to prepare eudragit-S100 nanoparticles loaded with curcumin by using solvent evaporation method and using tween 80 as surfactant. Previously formulated solution drug in IPA was used as dispersed phase and with 2% PVA solution 1% Tween 80 is dispersion medium and permitted for continuous stirring at least 3hr resulting in nanoparticle formation. Numerous parameters like rate of stirring, polymer concentration relative to drug and quantity of organic solvent were optimized. For optimizing the drug concentration, organic solvent and polymer, eight formulations were prepared by changing the solvent and polymer concentration. A comparison of the obtained results were made. On comparing the formulated preparations F-4 (1:4) was showing particles better entrapment efficiency (95.68%). In-vitro, studies of drug release were accomplished for a period of 12hrs and the released drug from the formulation was 46.02%. The results showed that as the ratio of polymer increases up-to fourth fold, encapsulation efficiency is enhanced and the rate of release is also sustained, but further increase in polymer show agglomeration of nanoparticles.