Polymeric nanoparticles in the treatment of neurodegenerative diseases: an overview

Abstract

This article present review of literature covering the use of numerous polymeric nanoparticles in the treatment of neurodegenerative disorders. It also throws a light on the barriers that hinder the delivery of drug to brain, the reasons for ineffective therapeutic action of drugs for treatment of NDs and why nanoparticles are preferred for treatment of neurodegenerative diseases. The blood brain barrier is main boundary that covers the brain and separates the neural tissues from circulating blood. It not only maintains homeostasis of brain but also obstructs the movement of drug molecules to brain. Due to this reason the CNS diseases cannot be treated properly. The incidence of neurodegenerative diseases is increasing with increasing population. Some of the most common NDs are Alzheimer disease and Parkinson disease. The barrier in the diagnosis and treatment of NDs is blood brain barrier. So, to overcome this problem attention is diverted to develop such novel drug delivery system that can carry dug to brain and can increase bioavailability in brain. Nanotechnology particularly use of nanoparticle can provide development in treatment of NDs.